Detalhe da pesquisa
1.
Rational design of balanced dual-targeting antibiotics with limited resistance.
PLoS Biol
; 18(10): e3000819, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33017402
2.
Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors.
Int J Mol Sci
; 23(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163706
3.
Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.
Drug Resist Updat
; 50: 100682, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32087558
4.
A New Cell-Based AI-2-Mediated Quorum Sensing Interference Assay in Screening of LsrK-Targeted Inhibitors.
Chembiochem
; 21(13): 1918-1922, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32026533
5.
Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.
Bioorg Chem
; 102: 104049, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32688116
6.
Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates.
Bioorg Chem
; 95: 103550, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31911309
7.
Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques.
Bioorg Chem
; 91: 103125, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31401373
8.
Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors.
Arch Pharm (Weinheim)
; 351(1)2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29239018
9.
Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors.
Bioorg Med Chem
; 25(1): 338-349, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27838171
10.
Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin.
Bioorg Med Chem Lett
; 24(11): 2530-4, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755428
11.
Action of clathrodin and analogues on voltage-gated sodium channels.
Mar Drugs
; 12(4): 2132-43, 2014 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24714127
12.
Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues.
Mar Drugs
; 12(2): 940-63, 2014 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24534840
13.
Evaluation of Michael-type acceptor reactivity of 5-benzylidenebarbiturates, 5-benzylidenerhodanines, and related heterocycles using NMR.
Acta Chim Slov
; 61(3): 637-44, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25286221
14.
A synthetic flavonoid derivate in the plasma membrane transforms the voltage-clamp fluorometry signal of CiHv1.
FEBS J
; 2024 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431775
15.
Three-dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes.
Eur J Immunol
; 42(12): 3429-41, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018451
16.
Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators.
J Chem Inf Model
; 53(12): 3223-32, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215100
17.
New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel.
Eur J Med Chem
; 258: 115530, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37329714
18.
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.
Eur J Med Chem
; 249: 115116, 2023 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36689894
19.
Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens.
ACS Omega
; 8(27): 24387-24395, 2023 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37457471
20.
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
J Med Chem
; 66(2): 1380-1425, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634346